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Literature summary for 2.7.8.13 extracted from

  • Zawadzke, L.E.; Wu, P.; Cook, L.; Fan, L.; Casperson, M.; Kishnani, M.; Calambur, D.; Hofstead, S.J.; Padmanabha, R.
    Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention (2003), Anal. Biochem., 314, 243-252.
    View publication on PubMed

Application

Application Comment Organism
medicine target for antimicrobial therapeutic intervention, novel antibiotic chemotypes must be developed to deter the alarming rate of antibiotic resistance growth Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
mraY gene cloned into pASK-IBA3 vector and overexpressed Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information MraY natural product inhibitors are not broad in spectrum nor practical for general antibiotic use Escherichia coli
mureidomycin A inhibitor isolated from Streptomyces flavidovirens WD31235, also antibacterial activity against Pseudomonas aeruginosa A27853 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate Escherichia coli
-
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor Escherichia coli
-
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
-
Escherichia coli lipid-P-P-MurNAc-pentapeptide + UMP
-
r
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
-
Escherichia coli UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
-
Escherichia coli UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r

Synonyms

Synonyms Comment Organism
MraY protein
-
Escherichia coli