Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | an integral membrane protein | Homo sapiens | 16020 | - |
microsome | - |
Homo sapiens | - |
- |
additional information | CPT/CEPT enzymes reside in multiple subcellular membranes that can move among organelles | Homo sapiens | - |
- |
nuclear membrane | - |
Homo sapiens | 31965 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-choline + 1,2-diacyl-sn-glycerol | Homo sapiens | - |
CMP + a phosphatidylcholine | - |
r | |
CDP-ethanolamine + 1,2-diacyl-sn-glycerol | Homo sapiens | - |
CMP + a phosphatidylethanolamine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y6K0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-choline + 1,2-diacyl-sn-glycerol | - |
Homo sapiens | CMP + a phosphatidylcholine | - |
r | |
CDP-ethanolamine + 1,2-diacyl-sn-glycerol | - |
Homo sapiens | CMP + a phosphatidylethanolamine | - |
r | |
additional information | the enzyme has dual specificity for both CDP-choline, EC 2.7.8.2, and CDP-ethanolamine | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CEPT | - |
Homo sapiens |
choline-ethanolamine phosphotransferase | - |
Homo sapiens |
CPT/CEPT | - |
Homo sapiens |
More | cf. EC 2.7.8.2 | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of the gene encoding CPT, EC 2.7.8.2, but not CEPT increases during lipopolysaccahride-induced endoplasmic reticulum biogenesis in B-lymphocytes | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | reduction of phosphatidylcholine, e.g. by bacterial infection, results in apoptosis | Homo sapiens |
metabolism | the CDP-choline and CDP-ethanolamine pathways are separate routes of phospholipid biosynthesis in mammalian cells, although the CEPT is probably a participant in both pathways. Physiological role of the CDP-choline pathway, overview | Homo sapiens |