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Literature summary for 2.7.8.1 extracted from
- Phosphatidylcholine and the CDP-choline cycle (2013), Biochim. Biophys. Acta, 1831, 523-532.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| membrane | an integral membrane protein | Homo sapiens | 16020 | - |
| microsome | - |
Homo sapiens | - |
- |
| additional information | CPT/CEPT enzymes reside in multiple subcellular membranes that can move among organelles | Homo sapiens | - |
- |
| nuclear membrane | - |
Homo sapiens | 31965 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-choline + 1,2-diacyl-sn-glycerol | Homo sapiens | - |
CMP + a phosphatidylcholine | - |
r |  |
| CDP-ethanolamine + 1,2-diacyl-sn-glycerol | Homo sapiens | - |
CMP + a phosphatidylethanolamine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9Y6K0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-choline + 1,2-diacyl-sn-glycerol | - |
Homo sapiens | CMP + a phosphatidylcholine | - |
r | |
| CDP-ethanolamine + 1,2-diacyl-sn-glycerol | - |
Homo sapiens | CMP + a phosphatidylethanolamine | - |
r | |
| additional information | the enzyme has dual specificity for both CDP-choline, EC 2.7.8.2, and CDP-ethanolamine | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CEPT | - |
Homo sapiens |
| choline-ethanolamine phosphotransferase | - |
Homo sapiens |
| CPT/CEPT | - |
Homo sapiens |
| More | cf. EC 2.7.8.2 | Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | expression of the gene encoding CPT, EC 2.7.8.2, but not CEPT increases during lipopolysaccahride-induced endoplasmic reticulum biogenesis in B-lymphocytes | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | reduction of phosphatidylcholine, e.g. by bacterial infection, results in apoptosis | Homo sapiens |
| metabolism | the CDP-choline and CDP-ethanolamine pathways are separate routes of phospholipid biosynthesis in mammalian cells, although the CEPT is probably a participant in both pathways. Physiological role of the CDP-choline pathway, overview | Homo sapiens |
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