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Literature summary for 2.7.8.1 extracted from
- Solubilization and purification of rat liver microsomal 1,2-diacylglycerol: CDP-choline cholinephosphotransferase and 1,2-diacylglycerol: CDP-ethanolamine ethanolaminephosphotransferase (1976), Eur. J. Biochem., 66, 201-210.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | activates | Rattus norvegicus |  |
| Triton X-100 | slightly stimulates with Mn2+, but not with Mg2+ as cofactor | Rattus norvegicus | |
General Stability
| General Stability | Organism |
|---|---|
| Triton X-100, stable to | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CDP-choline | - |
Rattus norvegicus | |
| ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetracetic acid | - |
Rattus norvegicus | |
| Microsomal phospholipids | - |
Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | negligible effect | Rattus norvegicus | |
| Mg2+ | can partially replace Mn2+ in activation | Rattus norvegicus | |
| Mn2+ | much more effective than Mg2+ | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 12.1 | - |
30°C, pH 8.5 | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-ethanolamine + 1,2-diacylglycerol | - |
Rattus norvegicus | CMP + a phosphatidylethanolamine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.5 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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