Literature summary for 2.7.7.B24 extracted from

Kato, K.; Ishii, R.; Hirano, S.; Ishitani, R.; Nureki, O.
Structural basis for the catalytic mechanism of DncV, bacterial homolog of cyclic GMP-AMP synthase (2015), Structure, 23, 843-850.

Search for more literature for 2.7.7.B24

Crystallization (Commentary)

Crystallization (Comment)	Organism
structure in complex with dGTP. DncV adopts an extended bilobed architecture characterized by a nucleotidyltransferase fold	Vibrio cholerae O1
structure of apo form and in complex with GTP and with dATP and dGTP, respectively. DncV adopts an extended bilobed architecture characterized by a nucleotidyltransferase fold. The ribose and triphosphate moieties of both GTP and ATP are bound to the donor and acceptor pockets in a similar manner. DncV efficiently catalyzes the phosphodiester linkage formation with ATP bound to the acceptor pocket, compared with GTP, thereby producing pppA(3'5')pG preferentially	Vibrio cholerae O1

Crystallization (Comment)

Organism

structure in complex with dGTP. DncV adopts an extended bilobed architecture characterized by a nucleotidyltransferase fold

Vibrio cholerae O1

structure of apo form and in complex with GTP and with dATP and dGTP, respectively. DncV adopts an extended bilobed architecture characterized by a nucleotidyltransferase fold. The ribose and triphosphate moieties of both GTP and ATP are bound to the donor and acceptor pockets in a similar manner. DncV efficiently catalyzes the phosphodiester linkage formation with ATP bound to the acceptor pocket, compared with GTP, thereby producing pppA(3'5')pG preferentially

Vibrio cholerae O1

Organism

Organism	UniProt	Comment	Textmining
Vibrio cholerae O1	Q6XGD8	-	-
Vibrio cholerae O1	Q9KVG7	-	-
Vibrio cholerae O1 ATCC 39315	Q6XGD8	-	-
Vibrio cholerae O1 ATCC 39315	Q9KVG7	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + GTP = 2 diphosphate + cyclic Gp(3'-5')G	(3)	Vibrio cholerae O1	a
GTP + ATP = 2 diphosphate + cyclic Gp(3'-5')A	(2)	Vibrio cholerae O1	a
GTP + GTP = 2 diphosphate + cyclic Gp(3'-5')G	(1)	Vibrio cholerae O1	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
ATP + GTP	-	Vibrio cholerae O1	2 diphosphate + cyclic Ap(3'-5')Gp	-	?
ATP + GTP	-	Vibrio cholerae O1 ATCC 39315	2 diphosphate + cyclic Ap(3'-5')Gp	-	?
GTP + ATP	-	Vibrio cholerae O1	2 diphosphate + cyclic Gp(3'-5')A	-	?
GTP + ATP	-	Vibrio cholerae O1 ATCC 39315	2 diphosphate + cyclic Gp(3'-5')A	-	?
GTP + GTP	-	Vibrio cholerae O1	2 diphosphate + cyclic Gp(3'-5')G	-	?
GTP + GTP	-	Vibrio cholerae O1 ATCC 39315	2 diphosphate + cyclic Gp(3'-5')G	-	?
additional information	DncV preferably recognizes ATP and GTP as acceptor and donor nucleotides, respectively, in the first nucleotidyl transfer reaction	Vibrio cholerae O1	?	-	?
additional information	DncV preferably recognizes ATP and GTP as acceptor and donor nucleotides, respectively, in the first nucleotidyl transfer reaction	Vibrio cholerae O1 ATCC 39315	?	-	?

Synonyms

Synonyms	Comment	Organism
3'-5'-cyclic AMP GMP cyclase	-	Vibrio cholerae O1
DncV	-	Vibrio cholerae O1
VC0179-like protein	-	Vibrio cholerae O1