Protein Variants | Comment | Organism |
---|---|---|
D131A/D133A | loss of catalytic activity | Vibrio cholerae O1 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Vibrio cholerae O1 | in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A | ? | - |
? | |
additional information | Vibrio cholerae O1 ATCC 39315 | in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Vibrio cholerae O1 | Q9KVG7 | - |
- |
Vibrio cholerae O1 ATCC 39315 | Q9KVG7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ATP | - |
Vibrio cholerae O1 | 2 diphosphate + cyclic Ap(3'-5')Ap | - |
? | |
ATP + ATP | - |
Vibrio cholerae O1 ATCC 39315 | 2 diphosphate + cyclic Ap(3'-5')Ap | - |
? | |
ATP + GTP | DncV preferentially synthesizes a hybrid c-AMP-GMP molecule from ATP and GTP | Vibrio cholerae O1 | 2 diphosphate + cyclic Ap(3'-5')Gp | - |
? | |
ATP + GTP | DncV preferentially synthesizes a hybrid c-AMP-GMP molecule from ATP and GTP | Vibrio cholerae O1 ATCC 39315 | 2 diphosphate + cyclic Ap(3'-5')Gp | - |
? | |
GTP + GTP | - |
Vibrio cholerae O1 | 2 diphosphate + cyclic Gp(3'-5')G | - |
? | |
GTP + GTP | - |
Vibrio cholerae O1 ATCC 39315 | 2 diphosphate + cyclic Gp(3'-5')G | - |
? | |
additional information | in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A | Vibrio cholerae O1 | ? | - |
? | |
additional information | no activity with TTP, UTP and CTP | Vibrio cholerae O1 | ? | - |
? | |
additional information | in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A | Vibrio cholerae O1 ATCC 39315 | ? | - |
? | |
additional information | no activity with TTP, UTP and CTP | Vibrio cholerae O1 ATCC 39315 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
di-nucleotide cyclase Vibrio | - |
Vibrio cholerae O1 |
VC0179 | - |
Vibrio cholerae O1 |
General Information | Comment | Organism |
---|---|---|
physiological function | disruption of the DncV gene causes a significant defect in intestinal colonization by Vibrio cholerae. Increased expression of DncV severely inhibits Vibrio cholerae chemotaxis, expression of DncV does not change overall motility | Vibrio cholerae O1 |