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Literature summary for 2.7.7.93 extracted from

  • Blodgett, J.A.; Thomas, P.M.; Li, G.; Velasquez, J.E.; van der Donk, W.A.; Kelleher, N.L.; Metcalf, W.W.
    Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide (2007), Nat. Chem. Biol., 3, 480-485.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces viridochromogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + phosphonoformate Streptomyces viridochromogenes
-
 CMP-5'-phosphonoformate + diphosphate
-
 ?
CTP + phosphonoformate Streptomyces viridochromogenes DSM 40736
-
 CMP-5'-phosphonoformate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces viridochromogenes Q5IW36
-
-
Streptomyces viridochromogenes DSM 40736 Q5IW36
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + phosphonoformate
-
 Streptomyces viridochromogenes CMP-5'-phosphonoformate + diphosphate
-
 ?
CTP + phosphonoformate
-
 Streptomyces viridochromogenes CMP-5'-phosphonoformate + diphosphate the enzyme catalyzes the displacement of the beta- and gamma-phosphates of CTP (as diphosphate) by phosphonoformate to produce the intermediate CMP-5'-phosphonoformate ?
CTP + phosphonoformate
-
 Streptomyces viridochromogenes DSM 40736 CMP-5'-phosphonoformate + diphosphate
-
 ?
CTP + phosphonoformate
-
 Streptomyces viridochromogenes DSM 40736 CMP-5'-phosphonoformate + diphosphate the enzyme catalyzes the displacement of the beta- and gamma-phosphates of CTP (as diphosphate) by phosphonoformate to produce the intermediate CMP-5'-phosphonoformate ?

Synonyms

Synonyms Comment Organism
phpF
-
 Streptomyces viridochromogenes

General Information

General Information Comment Organism
physiological function a PhpF deletion mutant fails to produce phosphinothricin after growth in malt-yeast-glucose broth. Culture supernatants from this mutant reveal two unique peaks, which correspond to phosphonoformate and phosphite, respectively Streptomyces viridochromogenes