Crystallization (Comment) | Organism |
---|---|
in the D4 octameric structure of the hUGP1-UDP-Glc complex, all subunits have the same overall conformation. The transition of the UGP octamer between the apo- and the product-bound forms is in agreement with the Monod-Wyman-Changeux symmetry model. oligomerzation facilitates an intermolecular stabilization of the sugar moiety in the active site (interlock mechanism), enhances protein stability, enables mild positive cooperativity observed for the octameric wild-type UGP1 towards diphosphate in the reverse reaction, and may allow regulation of the UGP octamer by modification of a single subunit | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D253L | 0.063% of wild-type activity | Homo sapiens |
G115D | 0.004% of wild-type activity | Homo sapiens |
G116A | 0.067% of wild-type activity | Homo sapiens |
G222A | insoluble protein | Homo sapiens |
H223L | insoluble protein | Homo sapiens |
K127A | 0.150% of wild-type activity | Homo sapiens |
K396A | 0.041% of wild-type activity | Homo sapiens |
L113G | insoluble protein | Homo sapiens |
N251L | 0.011% of wild-type activity | Homo sapiens |
N328L | insoluble protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16851 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
UPD1 | splicing variant | Homo sapiens |