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Literature summary for 2.7.7.89 extracted from

  • Carroll, P.; Pashley, C.; Parish, T.
    Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis (2008), J. Bacteriol., 190, 4894-4902.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
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Mycobacterium tuberculosis H37Rv
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Synonyms

Synonyms Comment Organism
GlnE
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Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function deletion of the deadenylylation domain has no apparent effect on growth or glutamine synthetase activity. In the presence of L-methionine sulfoximine, an inhibitor, and glutamine supplementation, a null mutant is able to grow similarly to the wild type. The GlnE mutant is able to survive and grow for extended periods in liquid medium, but not on solid medium, in the absence of glutamine synthetase inhibition Mycobacterium tuberculosis