Inhibitors | Comment | Organism | Structure |
---|---|---|---|
9-amino-6-chloro-2-methoxyacridine | antimalarial drug, inhibits dsDNA stimulation of cGAS. IC50 value for interferon IFN-beta 0.0053 mM | Homo sapiens | |
Quinacrine | antimalarial drug, inhibits dsDNA stimulation of cGAS. IC50 value for interferon IFN-beta 0.0037 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.013 | - |
pH 7.5, 22°C | Homo sapiens | Quinacrine | |
0.032 | - |
pH 7.5, 22°C | Homo sapiens | 9-amino-6-chloro-2-methoxyacridine |