Application | Comment | Organism |
---|---|---|
medicine | cGAS and Ifi204 cooperate to sense cytosolic dsDNA and rancisella. novicida infection to produce a strong type I IFN response | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | primary and immortalized murine macrophages | Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | cyclic GMP-AMP synthase cGAS and interferon activated gene Ifi204, are both required for the STING-dependent type I IFN response to Francisella novicida infection. cGAS and Ifi204 cooperate to sense dsDNA and activate the STING-dependent type I IFN pathway. dsDNA from Francisella novicida is an important type I IFN stimulating ligand. cGASSTING signaling leads to activation of the absent in melanoma 2 inflammasome in response to Francisella novicida infection. The absent in melanoma 2 inflammasome is beneficial to the host during Francisella novicida infection, type I IFN signaling by STING and IFN regulatory factor 3 is detrimental to the host | Mus musculus |