Protein Variants | Comment | Organism |
---|---|---|
G206S | single nucleotide polymorphism identified in in a faster growing but less resistant strain of an isogenic MRSA strain pair that differs in methicillin resistance levels and fitness | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | Q2FW92 | - |
- |
Staphylococcus aureus NCTC 8325 | Q2FW92 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
dacA | - |
Staphylococcus aureus |
SAOUHSC_02407 | - |
Staphylococcus aureus |
General Information | Comment | Organism |
---|---|---|
physiological function | introduction of single nucleotide polymorphism G206S into an isogenic highly resistant but slower growing strain reduces resistance and increases its growth rate, suggesting a direct connection between the dacA mutation and the phenotypic differences of these strains. The dacA mutation decreases cyclic di-AMP levels resulting in reduced autolysis, increased salt tolerance and a reduction in the basal expression of the cell wall stress stimulon | Staphylococcus aureus |