Literature summary for 2.7.7.85 extracted from

Cheng, X.; Zheng, X.; Zhou, X.; Zeng, J.; Ren, Z.; Xu, X.; Cheng, L.; Li, M.; Li, J.; Li, Y.
Regulation of oxidative response and extracellular polysaccharide synthesis by a diadenylate cyclase in Streptococcus mutans (2016), Environ. Microbiol., 18, 904-922.

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Organism

Organism	UniProt	Comment	Textmining
Streptococcus mutans	Q8DTC4	-	-
Streptococcus mutans UA159	Q8DTC4	-	-

Synonyms

Synonyms	Comment	Organism
CdaA	-	Streptococcus mutans
SMU_1428c	-	Streptococcus mutans

General Information

General Information	Comment	Organism
physiological function	in-frame deletion of the cdaA gene causes decreased cyclic di-AMP levels, increased sensitivity to hydrogen peroxide and increased production of extracellular polysaccharides. More than 200 genes are significantly upregulated or downregulated in the cdaA mutant. Genes with increased or decreased expression are clustered in cellular polysaccharide biosynthetic processes and oxidoreductase activity respectively. The expression of several genomic islands, such as GTFB/C, TnSmu, CRISPR1-Cas and CRISPR2-Cas, is altered in the cdaA mutant	Streptococcus mutans

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Release 2023.1 (January 2023)