Literature summary for 2.7.7.8 extracted from

Engman, J.; Negrea, A.; Sigurlasdottir, S.; Geoerg, M.; Eriksson, J.; Eriksson, O.S.; Kuwae, A.; Sjoelinder, H.; Jonsson, A.B.
Neisseria meningitidis polynucleotide phosphorylase affects aggregation, adhesion, and virulence (2016), Infect. Immun., 84, 1501-1513.

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Organism

Organism	UniProt	Comment	Textmining
Neisseria meningitidis FAM18	A1KT19	-	-
Neisseria meningitidis FAM18 DSM 15464	A1KT19	-	-

General Information

General Information	Comment	Organism
physiological function	deletion of the gene encoding PNPase leads to hyperaggregation and increased adhesion to epithelial cells. The aggregation induced is dependent on pili and mediated by excessive pilus bundling. PNPase expression is induced following bacterial attachment to human cells. Deletion of PNPase leads to global transcriptional changes and the differential regulation of 469 genes. PNPase is required for full virulence in an in vivo model of N. meningitidis infection	Neisseria meningitidis FAM18

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Release 2023.1 (January 2023)