Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neisseria meningitidis FAM18 | A1KT19 | - |
- |
Neisseria meningitidis FAM18 DSM 15464 | A1KT19 | - |
- |
General Information | Comment | Organism |
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physiological function | deletion of the gene encoding PNPase leads to hyperaggregation and increased adhesion to epithelial cells. The aggregation induced is dependent on pili and mediated by excessive pilus bundling. PNPase expression is induced following bacterial attachment to human cells. Deletion of PNPase leads to global transcriptional changes and the differential regulation of 469 genes. PNPase is required for full virulence in an in vivo model of N. meningitidis infection | Neisseria meningitidis FAM18 |