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Literature summary for 2.7.7.8 extracted from

  • Chen, R.; Weng, Y.; Zhu, F.; Jin, Y.; Liu, C.; Pan, X.; Xia, B.; Cheng, Z.; Jin, S.; Wu, W.
    Polynucleotide phosphorylase regulates multiple virulence factors and the stabilities of small RNAs RsmY/Z in Pseudomonas aeruginosa (2016), Front. Microbiol., 7, 247.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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General Information

General Information Comment Organism
physiological function the KH-S1 domains of PNPase are required for the type III secretion system (T3SS) and bacterial virulence. PNPase shows a pleiotropic role in gene regulation. The RNA level of exsA is decreased in a mutant lacking the KH-S1 domains. The pilus biosynthesis genes are down regulated and the type VI secretion system (T6SS) genes are up regulated in the mutant, which is caused by increased levels of small RNAs, RsmY, and RsmZ. Deletion of the KH-S1 domains does not affect the transcription of RsmY/Z, but increases their stabilities Pseudomonas aeruginosa