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Literature summary for 2.7.7.8 extracted from
- Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA (2008), RNA, 14, 310-323.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | stable silencing by establishing HeLa cell lines expressing shRNA. Silencing significantly affects processing and polyadenylation of mitochondrial mRNAs with different effects on different genes. The stable poly(A) tails at the 3' ends of COX1 transcripts are abolished, while COX3 poly(A) tails remain unaffected and ND5 and ND3 poly(A) extensions increase in length. Despite the lack of polyadenylation at the 3' end, COX1 mRNA and protein accumulate to normal levels, as is the case for all 13 mitochondria-encoded proteins. ATP depletion also alters poly(A) tail length | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | located to intermembrane space | Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
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