Literature summary for 2.7.7.8 extracted from

Ygberg, S.E.; Clements, M.O.; Rytkoenen, A.; Thompson, A.; Holden, D.W.; Hinton, J.C.; Rhen, M.
Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica (2006), Infect. Immun., 74, 1243-1254.

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Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme inactivation strain, PNPase deficiency results in increased expression of salmonella plasmid virulence genes. Six genes are significantly upregulated, including spvABC, rtcB, entC, and STM2236. A growth advantage of the mutant strain in BALB/c mice depends on plasmid virulence gene spvR as well	Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Salmonella enterica	enzyme is involved in tuning the expression of virulence genes and bacterial fitness during infection	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme is involved in tuning the expression of virulence genes and bacterial fitness during infection	Salmonella enterica	?	-	?

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Release 2023.1 (January 2023)