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Literature summary for 2.7.7.8 extracted from

  • Chou, J.Y.; Singer, M.F.
    Deoxyadenosine diphosphate as a substrate and inhibitor of polynucleotide phosphorylase of Micrococcus luteus. II. Inhibition of the initiation of adenosine diphosphate polymerization by deoxyadenosine diphosphate (1971), J. Biol. Chem., 246, 7497-7504.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dADP competitive inhibition of de novo polymerization of ADP by primer-independent form I and primer-dependent form T Micrococcus luteus

Organism

Organism UniProt Comment Textmining
Micrococcus luteus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(A) + ADP
-
Micrococcus luteus poly(A)+1 + phosphate
-
r
RNAn + a nucleoside diphosphate
-
Micrococcus luteus RNAn+1 + phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.003 0.004 dADP pH 9.0, 37°C, inhibition of ADP polymerization Micrococcus luteus