Literature summary for 2.7.7.70 extracted from

Kneidinger, B.; Marolda, C.; Graninger, M.; Zamyatina, A.; McArthur, F.; Kosma, P.; Valvano, M.A.; Messner, P.
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli (2002), J. Bacteriol., 184, 363-369.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glycero-beta-D-manno-heptose 1-phosphate + ATP	Escherichia coli	synthesis of ADP-D-beta-D-heptose in Escherichia coli requires three proteins, GmhA (sedoheptulose 7-phosphate isomerase), HldE (bifunctional D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase), and GmhB (D,D-heptose 1,7-bisphosphate phosphatase)	ADP-D-glycero-beta-D-manno-heptose + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P76658	bifunctional protein hldE includes: D-beta-D-heptose 7-phosphate kinase and D-beta-D-heptose 1-phosphate adenosyltransferase	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glycero-beta-D-manno-heptose 1-phosphate + ATP	-	Escherichia coli	ADP-D-glycero-beta-D-manno-heptose + diphosphate	-	?
D-glycero-beta-D-manno-heptose 1-phosphate + ATP	synthesis of ADP-D-beta-D-heptose in Escherichia coli requires three proteins, GmhA (sedoheptulose 7-phosphate isomerase), HldE (bifunctional D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase), and GmhB (D,D-heptose 1,7-bisphosphate phosphatase)	Escherichia coli	ADP-D-glycero-beta-D-manno-heptose + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase	bifunctional enzyme	Escherichia coli

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Release 2023.1 (January 2023)