Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)

Wang, L.; Huang, H.; Nguyen, H.H.; Allen, K.N.; Mariano, P.S.; Dunaway-Mariano, D.; Biochemistry 49, 1072-1081 (2010)

Data extracted from this reference:

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

D-glycero-beta-D-manno-heptose 1-phosphate + ATP

Bordetella bronchiseptica

-

ADP-D-glycero-beta-D-manno-heptose + diphosphate

-

-

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

D-glycero-beta-D-manno-heptose 1-phosphate + ATP

-

696367

Bordetella bronchiseptica

ADP-D-glycero-beta-D-manno-heptose + diphosphate

-

-

-

?

D-glycero-beta-D-manno-heptose 1-phosphate + ATP

no product is obtained when GTP, UTP or CTP is substituted for ATP

696367

Bordetella bronchiseptica

ADP-D-glycero-beta-D-manno-heptose + diphosphate

-

-

-

?

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

D-glycero-beta-D-manno-heptose 1-phosphate + ATP

Bordetella bronchiseptica

-

ADP-D-glycero-beta-D-manno-heptose + diphosphate

-

-

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

D-glycero-beta-D-manno-heptose 1-phosphate + ATP

-

696367

Bordetella bronchiseptica

ADP-D-glycero-beta-D-manno-heptose + diphosphate

-

-

-

?

D-glycero-beta-D-manno-heptose 1-phosphate + ATP

no product is obtained when GTP, UTP or CTP is substituted for ATP

696367

Bordetella bronchiseptica

ADP-D-glycero-beta-D-manno-heptose + diphosphate

-

-

-

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

696367

Wang

Divergence of biochemical func ...

Bordetella bronchiseptica

Biochemistry

49

1072-1081

2010

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1

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698565

Kneidinger

Biosynthesis pathway of ADP-L- ...

Escherichia coli

J. Bacteriol.

184

363-369

2002

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700026

Valvano

Novel pathways for biosynthesi ...

Escherichia coli

Microbiology

148

1979-1989

2002

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1

1

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698557

Valvano

The rfaE gene from Escherichia ...

Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium

J. Bacteriol.

182

488-497

2000

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