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Literature summary for 2.7.7.7 extracted from

  • Sherrer, S.M.; Taggart, D.J.; Pack, L.R.; Malik, C.K.; Basu, A.K.; Suo, Z.
    Quantitative analysis of the mutagenic potential of 1-aminopyrene-DNA adduct bypass catalyzed by Y-family DNA polymerases (2012), Mutat. Res., 737, 25-33.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Saccharolobus solfataricus
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diphosphate + DNAn+1
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?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
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Saccharolobus solfataricus diphosphate + DNAn+1
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?
deoxynucleoside triphosphate + DNAn relative to undamaged DNA the enzyme generates far more mutations (base deletions, insertions, and substitutions) with a DNA template containing a site-specifically placed N-(deoxyguanosin-8-yl)-1-aminopyrene. Opposite N-(deoxyguanosin-8-yl)-1-aminopyrened and at an immediate downstream template position, the most frequent base substitutions are dA Saccharolobus solfataricus diphosphate + DNAn+1
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?

Synonyms

Synonyms Comment Organism
DNA polymerase IV
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Saccharolobus solfataricus
Dpo4
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Saccharolobus solfataricus