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Literature summary for 2.7.7.7 extracted from

  • Henneke, G.; Flament, D.; Huebscher, U.; Querellou, J.; Raffin, J.P.
    The hyperthermophilic euryarchaeota Pyrococcus abyssi likely requires the two DNA polymerases D and B for DNA replication (2005), J. Mol. Biol., 350, 53-64.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Pyrococcus abyssi PabPolD might play an important role in DNA replication likely together with PabpolB, suggesting that archaea require two DNA polymerases at the replication fork diphosphate + DNAn+1
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Organism

Organism UniProt Comment Textmining
Pyrococcus abyssi
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn PabPolD might play an important role in DNA replication likely together with PabpolB, suggesting that archaea require two DNA polymerases at the replication fork Pyrococcus abyssi diphosphate + DNAn+1
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deoxynucleoside triphosphate + DNAn both DNA polymerase D and DNA polymerases B are DNA polymerizing enzymes exclusively. DNA polymerase D has a preference for a primed template. DNA polymerase D is a primer-directed DNA polymerase independently of the primer composition whereas DNA polymerase B behaves as an exclusively DNA primer-directed DNA polymerase. Proliferating cell nuclear antigen is required for DNA polymerases D to perform efficient DNA synthesis but not DNA polymerases B. DNA polymerase D, but not DNA polymerase B, contains strand displacement activity. In the presence of PabPCNA, however, both DNA polymerases D and B show strand displacement activity. Direct interaction between DNA polymerase D and proliferating cell nuclear antigen is DNA-dependent Pyrococcus abyssi diphosphate + DNAn+1
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Synonyms

Synonyms Comment Organism
DNA polymerases B
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Pyrococcus abyssi
DNA polymerases D
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Pyrococcus abyssi
PabpolB
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Pyrococcus abyssi
PabpolD
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Pyrococcus abyssi