Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.7 extracted from

  • Cavanaugh, N.A.; Kuchta, R.D.
    Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha (2009), J. Biol. Chem., 284, 1523-1532.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human alphaherpesvirus 1 comparing RNA primer-templates and DNA primer templates of identical sequence show that herpes polymerase greatly prefers to elongate the DNA primer by 650-26000fold, thus accounting for the extremely low efficiency with which herpes polymerase elongates primase-synthesized primers ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Human alphaherpesvirus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn herpes polymerase only elongates primase-synthesized primers at least 8 nucleotides long Human alphaherpesvirus 1 diphosphate + DNAn+1
-
?
additional information comparing RNA primer-templates and DNA primer templates of identical sequence show that herpes polymerase greatly prefers to elongate the DNA primer by 650-26000fold, thus accounting for the extremely low efficiency with which herpes polymerase elongates primase-synthesized primers Human alphaherpesvirus 1 ?
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase
-
Human alphaherpesvirus 1
DNA polymerase alpha
-
Homo sapiens
pol alpha
-
Homo sapiens
UL30/UL42
-
Human alphaherpesvirus 1

General Information

General Information Comment Organism
physiological function polymerase alpha (p70-p180 or p49-p58-p70-p180 complex) extends herpes primase-synthesized RNA primers much more efficiently than herpes polymerase Homo sapiens