Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | DNA polymerase alpha is not inhibited by vitamin K1, vitamin K2, and vitamin K3 | Bos taurus | |
additional information | DNA polymerase isozymes are not inhibited by vitamin K1 and vitamin K2 | Homo sapiens | |
additional information | DNA polymerase beta is not inhibited by vitamin K1, vitamin K2, and vitamin K3 | Rattus norvegicus | |
vitamin K3 | more than 80% inhibition of pol gamma at 0.03 mM, does not affect other human DNA polymerase isozymes | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
thymus | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Rattus norvegicus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Bos taurus | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase | - |
Homo sapiens |
DNA polymerase alpha | - |
Bos taurus |
DNA polymerase beta | - |
Rattus norvegicus |
pol alpha | isozyme | Bos taurus |
pol beta | - |
Rattus norvegicus |
pol delta | isozyme | Homo sapiens |
POl epsilon | isozyme | Homo sapiens |
Pol eta | isozyme | Homo sapiens |
Pol gamma | isozyme | Homo sapiens |
pol iota | isozyme | Homo sapiens |
pol kappa | isozyme | Homo sapiens |
Pol lambda | isozyme | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.006 | - |
isozyme pol gamma, in 50 mM Tris-HCl (pH 7.5) containing 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Homo sapiens | vitamin K3 |