Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.7 extracted from

  • Mazzucco, C.E.; Hamatake, R.K.; Colonno, R.J.; Tenney, D.J.
    Entecavir for treatment of hepatitis B virus displays no in vitro mitochondrial toxicity or DNA polymerase gamma inhibition (2008), Antimicrob. Agents Chemother., 52, 598-605.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
adefovir diphosphate
-
 Drosophila melanogaster
lamivudine triphosphate
-
 Drosophila melanogaster
additional information no inhibition by entecavir Drosophila melanogaster
tenofovir diphosphate
-
 Drosophila melanogaster
zalcitabine triphosphate
-
 Drosophila melanogaster
zidovudine triphosphate
-
 Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00012
-
 2'-deoxyguanosine triphosphate in 50 mM Tris-HCl (pH 7.6), 100 mM KCl, 5 mM MgCl2, 10% (v/v) glycerol, 1 mM dithiothreitol, at 30°C Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Drosophila melanogaster 5739
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyguanosine triphosphate + DNAn
-
 Drosophila melanogaster diphosphate + DNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
DNA polymerase gamma
-
 Drosophila melanogaster
Pol gamma
-
 Drosophila melanogaster