Literature summary for 2.7.7.7 extracted from

Jiang, C.; Hwang, Y.T.; Randell, J.C.; Coen, D.M.; Hwang, C.B.
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication (2007), J. Virol., 81, 3495-3502.

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Protein Variants

Protein Variants	Comment	Organism
R113A	mutation reduces viral yield (2fold), alters the kinetics of viral DNA replication, and decreases the fidelity of DNA replication	Herpes simplex virus
R182A	mutation reduces viral yield (2fold), alters the kinetics of viral DNA replication, and decreases the fidelity of DNA replication	Herpes simplex virus
R279A	mutation reduces viral yield (5fold), alters the kinetics of viral DNA replication, and decreases the fidelity of DNA replication	Herpes simplex virus
R280A	mutation reduces viral yield (5fold), alters the kinetics of viral DNA replication, and decreases the fidelity of DNA replication	Herpes simplex virus

Organism

Organism	UniProt	Comment	Textmining
Herpes simplex virus	-	-	-

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Release 2023.1 (January 2023)