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BRENDA support

Literature summary for 2.7.7.7 extracted from

  • Kim, T.W.; Brieba, L.G.; Ellenberger, T.; Kool, E.T.
    Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs (2006), J. Biol. Chem., 281, 2289-2295.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
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additional information
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Escherichia phage T7

Organism

Organism UniProt Comment Textmining
Escherichia phage T7
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn the effects of varied DNA substrate size on the synthesis of DNA by the high fidelity T7 DNA polymerase: the T7 enzyme is highly sensitive in kinetic efficiency to size changes across this analog series. The T7 enzyme shows a strong dependence on substrate size and shows a preference for smaller substrates Escherichia phage T7 diphosphate + DNAn+1
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