Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',3'-dideoxythymidine 5'-triphosphate | - |
Toxoplasma gondii | |
K+ | optimum concentration 50 mM, inhibition at higher concentration | Toxoplasma gondii | |
additional information | enzyme is not inhibited by cytosine-beta-D-arabinofuranoside 5'-triphosphate which is an inhibitor of alpha-polymerase, monoclonal antibodies against human DNA polymerase alpha do not bind; no inhibition by aphidicolin | Toxoplasma gondii | |
N-ethylmaleimide | - |
Toxoplasma gondii | |
Salt | sensitive to high ionic strength | Toxoplasma gondii |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | stimulates at 50 mM, inhibition at higher concentrations | Toxoplasma gondii | |
Mg2+ | required | Toxoplasma gondii | |
Mg2+ | optimal concentration: 6 mM | Toxoplasma gondii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
150000 | - |
sedimentation experiments | Toxoplasma gondii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | Toxoplasma gondii | - |
diphosphate + DNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
tachyzoite | - |
Toxoplasma gondii | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Toxoplasma gondii | diphosphate + DNAn+1 | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Toxoplasma gondii |