Literature summary for 2.7.7.7 extracted from

Taguchi, T.; Matsukage, A.; Ito, H.; Saito, Y.; Kawashima, S.
Inhibition of DNA polymerases by tripeptide derivative protease inhibitors (1992), Biochem. Biophys. Res. Commun., 185, 1133-1140.

Search for more literature for 2.7.7.7

Inhibitors

Inhibitors	Comment	Organism	Structure
Benzyloxycarbonyl-Leu-Leu-al	-	Escherichia coli
Benzyloxycarbonyl-Leu-Leu-al	-	Rattus norvegicus
Dansyl-Leu-Leu-Leu-CH2Cl	inhibition of pol I	Escherichia coli
Dansyl-Leu-Leu-Leu-CH2Cl	inhibition of polymerase alpha, beta and gamma	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	Escherichia coli	-	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	Rattus norvegicus	-	diphosphate + DNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Escherichia coli	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	-	Rattus norvegicus	diphosphate + DNAn+1	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0625	-	Dansyl-Leu-Leu-Leu-CH2Cl	pH 8.3, 37°C	Rattus norvegicus
0.0656	-	Benzyloxycarbonyl-Leu-Leu-al	pH 8.3, 37°C	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)