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Literature summary for 2.7.7.7 extracted from

  • Murakami-Murofushi, K.; Shioda, M.; Kaji, K.; Yoshida, S.; Murofushi, H.
    Inhibition of eukaryotic DNA polymerase alpha with a novel lysophosphatidic acid (PHYLPA) isolated from myxoamoebae of Physarum polycephalum (1992), J. Biol. Chem., 267, 21512-21517.
    View publication on PubMed
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
lysophosphatidic acid isolated from myxamoebae of Physarum polycephalum, 90% inhibition of polymerase alpha, weak inhibitor of polymerase beta Bos taurus
lysophosphatidic acid weak inhibitor Escherichia coli
additional information
-
 Bos taurus
additional information no inhibition of DNA polymerase beta or gamma from various eukaryotic species, DNA polymerase I from E. coli by lysophosphatidic acid Escherichia coli
additional information no inhibition of DNA polymerase beta or gamma from various eukaryotic species, DNA polymerase I from E. coli by lysophosphatidic acid Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Mammalia
-
 diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Escherichia coli
-
 diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Bos taurus
-
 diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Escherichia coli
-
-
-
Mammalia
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Mammalia diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn
-
 Escherichia coli diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?