Literature summary for 2.7.7.7 extracted from

Simbulan, C.M.G.; Taki, T.; Tamiya-Koizumi, K.; Suzuki, M.; Savoysky, E.; Shoji, M.; Yoshida, S.
Sulfate- and sialic acid-containing glycolipids inhibit DNA polymerase alpha activity (1994), Biochim. Biophys. Acta, 1205, 68-74.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cerebroside sulfate ester	inhibition of polymerase alpha and gamma	Bos taurus
glycolipids	sulfate- and sialic acid-containing	Bos taurus
sphingosine	polymerase alpha and beta	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	Bos taurus	-	diphosphate + DNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	polymerase alpha	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Bos taurus	diphosphate + DNAn+1	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0004	-	cerebroside sulfate ester	pH 7.2, 37°C	Bos taurus
0.006	-	sphingosine	pH 7.2, 37°C	Bos taurus

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Release 2023.1 (January 2023)