Literature summary for 2.7.7.65 extracted from

Ohana, P.; Delmer, D.P.; Volman, G.; Benziman, M.
Glycosylated triterpenoid saponin: a specific inhibitor of diguanylate cyclase from Acetobacter xylinum. Biological activity and distribution (1998), Plant Cell Physiol., 39, 153-159.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-galactopyranosyl-(1-2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	noncompetitive, inhibition is decreased by 50% in presence of 0.02 mM cyclic diguanylate, no inhibition in presence of detergents. Inhibitor affects binding of cyclic diguanylate to enzyme. In situ, inhibitor affects bacterial cellulose synthesis and enzyme activity	Komagataeibacter xylinus
papulacandin B	-	Komagataeibacter xylinus

Organism

Organism	UniProt	Comment	Textmining
Komagataeibacter xylinus	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.005	-	3-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-galactopyranosyl-(1-2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	pH 7.5, 30°C	Komagataeibacter xylinus
0.07	-	papulacandin B	pH 7.5, 30°C	Komagataeibacter xylinus

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Release 2023.1 (January 2023)