Literature summary for 2.7.7.65 extracted from

Paul, R.; Weiser, S.; Amiot, N.C.; Chan, C.; Schirmer, T.; Giese, B.; Jenal, U.
Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain (2004), Genes Dev., 18, 715-727.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression as GFP fusion protein for subcellular targeting, expression with His-tag in Escherichia coli	Caulobacter vibrioides

Inhibitors

Inhibitors	Comment	Organism	Structure
cyclic di-3',5'-guanlylate	strong product inhibition	Caulobacter vibrioides

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell pole	response regulator PleD-GFP protein specifically localizes to the stalked pole and is absent from the flagellated swarmer pole. Targeting of PleD to the cell pole is coupled to the activation of its C-terminal di-guanylate cyclase domain	Caulobacter vibrioides	60187	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP	Caulobacter vibrioides	diguanylate cyclase activity constitutes the signaling output of the PleD response regulator	cyclic di-3',5'-guanylate + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Caulobacter vibrioides	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	localization of response regulator PleD to the stalked pole requires its activation by phosphorylation and is dependent on the polar kinases DivJ and PleC	Caulobacter vibrioides

Purification (Commentary)

Purification (Comment)	Organism
recombinant protein	Caulobacter vibrioides

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Caulobacter vibrioides	cyclic di-3',5'-guanylate + diphosphate	-	?
GTP	diguanylate cyclase activity constitutes the signaling output of the PleD response regulator	Caulobacter vibrioides	cyclic di-3',5'-guanylate + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
PleD	-	Caulobacter vibrioides

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Release 2023.1 (January 2023)