Literature summary for 2.7.7.6 extracted from

Morrill, S.A.; Exner, A.E.; Babokhov, M.; Reinfeld, B.I.; Fuchs, S.M.
DNA instability maintains the repeat length of the yeast RNA polymerase II C-terminal domain (2016), J. Biol. Chem., 291, 11540-11550.

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Cloned(Commentary)

Cloned (Comment)	Organism
C-terminal domain encoding DNA and amino acid sequence determination and analysis, genotyping, sequence comparisons of the CTD region from 36 yeast strains. The DNA helicase Pif1 suppresses CTD rearrangement	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-
Saccharomyces cerevisiae GRY3019	-	-	-

Subunits

Subunits	Comment	Organism
More	the C-terminal domain (CTD) of RNA polymerase II in eukaryotes is comprised of tandemly repeating units of a conserved seven-amino acid sequence. DNA instability may play a role in regulating or maintaining C-terminal domain repeat number. 36 diverse Saccharomyces cerevisiae isolates reveal evidence of numerous past rearrangements within the DNA sequence that encodes the C-terminal domain, the total number of CTD repeats is relatively static (24-26 repeats in all strains), suggesting a balancing act between repeat expansion and contraction. Presence of DNA secondary structures, specifically G-quadruplex-like DNA,within the CTD coding region. Mutating PIF1, a G-quadruplex-specific helicase, results in increased CTD repeat length polymorphisms. RAD52 is necessary for CTD repeat expansion but not contraction, identifying a role for recombination in repeat expansion	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
RNA polymerase II	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)