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Literature summary for 2.7.7.6 extracted from

  • Fuste, J.M.; Wanrooij, S.; Jemt, E.; Granycome, C.E.; Cluett, T.J.; Shi, Y.; Atanassova, N.; Holt, I.J.; Gustafsson, C.M.; Falkenberg, M.
    Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication (2010), Mol. Cell, 37, 67-78.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information combined shRNA and dsRNA POLRMT gene silencing Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information POLRMT can act as a primase in vitro and support lagging-strand DNA synthesis on a small 70 bp minicircle, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
mitochondrial RNA polymerase
-
Homo sapiens
POLRMT
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Homo sapiens

General Information

General Information Comment Organism
malfunction replication intermediates associated with an unusually prolonged delay in the initiation of second strand DNA synthesis are enhanced by combined shRNA and dsRNA POLRMT gene silencing Homo sapiens
physiological function mitochondrial DNA is replicated by a unique enzymatic machinery involving the POLRMT-mediated initiation of primer synthesis from a poly-dT stretch in the single-stranded loop region of the light-strand origin of DNA replication, when the single-stranded origin of DNA replication is exposed and adopts a stem-loop structure. The poly-dT repeat region of origin of DNA replication is an essential element for primer synthesis. POLRMT can function as an origin-specific primase in mammalian mitochondria, overview Homo sapiens