Literature summary for 2.7.7.6 extracted from

Kazuno, H.; Fujioka, A.; Fukushima, M.; Wataya, Y.; Matsuda, A.; Sasaki, T.
1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo (2009), Int. J. Oncol., 34, 1373-1380.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine	i.e. ECyd, TAS-106, a antitumor ribonucleoside that inhibits RNA polymerase, acts synergistically in inhibiting A-549 cancer cell growth and in tumor growth in vivo. The compound also inhibits the checkpoint-associated protein, the expression of Chk1 protein and the phosphorylation of Chk1 and Chk2, antitumour effects in combination with cisplatin, overview	Homo sapiens
3'-ethynylcytidine-5'-triphosphate	i.e. ECTP, competitive inhibition in the presence of isolated nuclei from FM3A mouse tumor cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
carcinoma cell	-	Homo sapiens	-
lung cancer cell	-	Homo sapiens	-
oral cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
RNA polymerase	-	Homo sapiens

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Release 2023.1 (January 2023)