Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme complex requires multiple transcription factors and protein interactions for activity, e.g. Spt6, overview | Drosophila melanogaster | |
Spt6 | transcription factor, Pol II shows a broad requirement for essential Spt6 during different stages of development, e.g. for for maximal recruitment of Paf1 and Spt5 to transcriptionally active Hsp70. Spt6 interacts with both nucleosome structure and Pol II, it has a role in elongation, directed RNAi knock-down of Spt6 reduces the elongation rate, the Spt6-dependent effect on elongation rate persists during steady-state-induced transcription, reducing the elongation rate from about 1100 to 500 bp/min. Stimulation of Pol II elongation rate by Spt6 is not mediated through transcription factor TFIIS | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
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Drosophila melanogaster | - |
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- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
S2 cell | - |
Drosophila melanogaster | - |
salivary gland | - |
Drosophila melanogaster | - |
Synonyms | Comment | Organism |
---|---|---|
Pol II | - |
Drosophila melanogaster |
RNA polymerase II | - |
Drosophila melanogaster |