Literature summary for 2.7.7.6 extracted from

Proshkina, G.M.; Shematorova, E.K.; Proshkin, S.A.; Zaros, C.; Thuriaux, P.; Shpakovski, G.V.
Ancient origin, functional conservation and fast evolution of DNA-dependent RNA polymerase III (2006), Nucleic Acids Res., 34, 3615-3624.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Schizosaccharomyces pombe

Organism

Organism	UniProt	Comment	Textmining
Schizosaccharomyces pombe	-	-	-

Subunits

Subunits	Comment	Organism
oligomer	RNA polymerase III contains seventeen subunits. The Schizosaccharomyces pombe subunits are expressed in Saccharomyces cerevisiae null mutants and tested for growth. Ten core subunits show heterospecific complementation, but the two largest catalytic subunits (Rpc1 and Rpc2) and all five RNA polymerase III-specific subunits (Rpc82, Rpc53, Rpc37, Rpc34 and Rpc31) are non-functional. Three highly conserved RNA polymerase III-specific domains are found in the twelve-subunit core structure. They correspond to the Rpc17-Rpc25 dimer, involved in transcription initiation, to an N-terminal domain of the largest subunit Rpc1 important to anchor Rpc31, Rpc34 and Rpc82, and to a C-terminal domain of Rpc1 that presumably holds Rpc37, Rpc53 and their Rpc11 partner	Schizosaccharomyces pombe

Synonyms

Synonyms	Comment	Organism
DNA-dependent RNA polymerase III	-	Schizosaccharomyces pombe

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Release 2023.1 (January 2023)