Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a promising target for the discovery of new antimicrobial agents | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ABI-1131 | - |
Escherichia coli | |
CBR-703 | - |
Escherichia coli | |
corallopyronin A | - |
Escherichia coli | |
GE-23077-A | - |
Escherichia coli | |
GE-23077-B | - |
Escherichia coli | |
lipiarmycin | - |
Escherichia coli | |
additional information | despite relatively high overall sequence and structural homology between bacterial and mammalian core RNAP enzymes, there are sufficient differences between the enzyme classes for exploitation in the discovery of selective bacterial inhibitors | Escherichia coli | |
myxopyronin A | - |
Escherichia coli | |
rifabutin | - |
Escherichia coli | |
rifalazil | - |
Escherichia coli | |
ripostatin A | - |
Escherichia coli | |
SB-2 | - |
Escherichia coli | |
sorangicin A | - |
Escherichia coli | |
Streptolydigin | - |
Escherichia coli | |
ureidothiophene | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Escherichia coli | enzyme is responsible for transcription in bacteria | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Escherichia coli | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | enzyme is responsible for transcription in bacteria | Escherichia coli | diphosphate + RNAn+1 | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the core of the procaryotic RNAP comprises five subunits | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
RNAP | - |
Escherichia coli |