Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Drosophila melanogaster | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9VI58 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + RNAn | - |
Drosophila melanogaster | diphosphate + RNAn+1 | enzyme preferentially uridylates mirtron hairpins | ? |
Synonyms | Comment | Organism |
---|---|---|
terminal uridylyltransferase Tailor | - |
Drosophila melanogaster |
TNTase CG1091 | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform Tailor preferentially uridylates mirtron hairpins, thereby impeding the production of non-canonical microRNAs. Mirtron selectivity is explained by primary sequence specificity of Tailor, selecting substrates ending with a 3'-guanosine. In contrast to mirtrons, conserved Drosophila precursor micro-RNAs are significantly depleted in 3'-guanosine, thereby escaping regulatory uridylation. Cytoplasmic Tailor is required for miRNA uridylation and normal fertility in flies | Drosophila melanogaster |