Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.52 extracted from

  • Gott, J.M.
    Two distinct roles for terminal uridylyl transferases in RNA editing (2003), Proc. Natl. Acad. Sci. USA, 100, 10583-10584.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
kinetoplast
-
Trypanosoma brucei 20023
-
mitochondrion 2 isozymes RET1 and RET2 in mitochondria editosomes Trypanosoma brucei 5739
-
additional information isozymes are located in 2 different complexes Trypanosoma brucei
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei reduction of isozyme RET1 leads to decrease in edited RNA and inhibited growth, lowers the uridine insertion and leads predominantly to shorter gRNAs ?
-
?
additional information Trypanosoma brucei down-regulation of isozyme RET2 inhibits growth and in vivo uridine insertion, but has no effect on the length of gRNAs ?
-
?
additional information Trypanosoma brucei many editing changes are developmentally regulated ?
-
?
UTP + RNAn Trypanosoma brucei involved in uridine insertion in the editing process of RNA diphosphate + RNAn+1
-
?
UTP + RNAn Trypanosoma brucei responsible for post-transcriptional RNA editing process of mitochondrial transcripts in kinetoplastid protozoans diphosphate + RNAn+1
-
?
UTP + RNAn Trypanosoma brucei addition of non-coded poly(U) tail to gRNAs diphosphate + RNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
RET1 and RET2, i.e. RNA editing TUTases 1 and 2, as components of different editing complexes
-

Reaction

Reaction Comment Organism Reaction ID
UTP + RNAn = diphosphate + RNAn+3'-U mechanism, uridine insertion in the editing process Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information reduction of isozyme RET1 leads to decrease in edited RNA and inhibited growth, lowers the uridine insertion and leads predominantly to shorter gRNAs Trypanosoma brucei ?
-
?
additional information down-regulation of isozyme RET2 inhibits growth and in vivo uridine insertion, but has no effect on the length of gRNAs Trypanosoma brucei ?
-
?
additional information many editing changes are developmentally regulated Trypanosoma brucei ?
-
?
UTP + RNAn kinetoplast RNA Trypanosoma brucei diphosphate + RNAn+1
-
?
UTP + RNAn involved in uridine insertion in the editing process of RNA Trypanosoma brucei diphosphate + RNAn+1
-
?
UTP + RNAn responsible for post-transcriptional RNA editing process of mitochondrial transcripts in kinetoplastid protozoans Trypanosoma brucei diphosphate + RNAn+1
-
?
UTP + RNAn addition of non-coded poly(U) tail to gRNAs Trypanosoma brucei diphosphate + RNAn+1
-
?

Synonyms

Synonyms Comment Organism
RET i.e. RNA editing TUTase Trypanosoma brucei