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Literature summary for 2.7.7.50 extracted from
- Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions (1975), J. Biol. Chem., 250, 9330-9335.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diphosphate | - |
Vaccinia virus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| viral nucleocapsid | - |
Vaccinia virus | 19013 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Vaccinia virus | |
| Mn2+ | can partially replace Mg2+ in activation | Vaccinia virus | |
| Mn2+ | 11% of the activity with Mg2+ | Vaccinia virus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Vaccinia virus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + pp(5')RNA | specific for GTP | Vaccinia virus | G(5')ppp(5')RNA + diphosphate | guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue | r | |
| additional information | no acceptor: RNA with a single 5'-terminal phosphate | Vaccinia virus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Vaccinia virus |
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