Literature summary for 2.7.7.49 extracted from

Bochner, R.; Duvshani, A.; Adir, N.; Hizi, A.
Mutagenesis of Gln294 of the reverse transcriptase of human immunodeficiency virus type-2 and its effects on the ribonuclease H activity (2008), FEBS Lett., 582, 2799-2805.

Search for more literature for 2.7.7.49

Protein Variants

Protein Variants	Comment	Organism
Q294A	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (12% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294C	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (34% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294E	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (11% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294H	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (16% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294M	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (4% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294N	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (36% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294P	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (13% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294R	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (35% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294S	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (19% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294W	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (13% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2
Q294Y	the mutation has no significant effect on the noticeable level of the DNA polymerase activity of the enzyme (3% increase of activity compared to the wild type enzyme)	Human immunodeficiency virus 2

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 2	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Human immunodeficiency virus 2	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase	-	Human immunodeficiency virus 2
reverse transcriptase	reverse transcriptases of retroviruses have two enzymatic activities, a DNA polymerase (that copies both RNA and DNA templates) and the ribonuclease H activity that hydrolyzes the RNA in DNA-RNA hybrids, the ribonuclease H level of HIV-2 RT is lower than that of HIV-1 reverse transcriptase, while the DNA polymerase of both reverse transcriptases is similar	Human immunodeficiency virus 2

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Release 2023.1 (January 2023)