Literature summary for 2.7.7.49 extracted from

Antunes, A.M.; Duarte, M.P.; Santos, P.P.; Gamboa da Costa, G.; Heinze, T.M.; Beland, F.A.; Marques, M.M.
Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine (2008), Chem. Res. Toxicol., 21, 1443-1456.

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Inhibitors

Inhibitors	Comment	Organism	Structure
12-(deoxyadenosin-N1-yl)nevirapine	-	Human immunodeficiency virus 1
12-(deoxyadenosin-N6-yl)nevirapine	-	Human immunodeficiency virus 1
12-(deoxycytidin-N3-yl)nevirapine	-	Human immunodeficiency virus 1
12-(deoxyguanosin-O6-yl)nevirapine	-	Human immunodeficiency virus 1
12-hydroxy-nevirapine	-	Human immunodeficiency virus 1
nevirapine	neviparine is 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Human immunodeficiency virus 1	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
reverse transcriptase	-	Human immunodeficiency virus 1

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Release 2023.1 (January 2023)