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Literature summary for 2.7.7.49 extracted from

  • Wang, L.Z.; Kenyon, G.L.; Johnson, K.A.
    Novel mechanism of inhibition of HIV-1 reverse transcriptase by a new non-nucleoside analog, KM-1 (2004), J. Biol. Chem., 279, 38424-38432.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-naphthalenesulfonic acid in the ternary enzyme-DNA-inhibitor complex, incorporation of the next nucleotide onto the primer is blocked. KM-1 can bind to the enzyme in both the absence and presence of DNA but weakens the affinity for DNA 140fold so that it favors DNA dissociation. KM-1 distorts enzyme conformation and misaligns DNA at the active site Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
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