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Literature summary for 2.7.7.49 extracted from

  • Liu, D.K.; Owens, G.F.
    Inhibition of viral reverse transcriptase by 2,5-oligoadenylates (1987), Biochem. Biophys. Res. Commun., 145, 291-297.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2',5'-Oligoadenylate mixed type inhibition, not strictly competitive with dTTP. Inhibition is most dramatic in the absence of sulfhydryl reagents and is reduced when either dithiothreitol or 2-mercaptoethanol are included in the reaction. Partial protection at 0.1 mM dithiothreitol, significant protection at 1 mM or above Avian myeloblastosis virus

Organism

Organism UniProt Comment Textmining
Avian myeloblastosis virus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
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Avian myeloblastosis virus diphosphate + DNAn+1
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