Literature summary for 2.7.7.49 extracted from

Chandra, A.; Gerber, T.; Chandra, P.
Biochemical heterogeneity of reverse transcriptase purified from the AIDS virus, HTLV-III (1986), FEBS Lett., 197, 84-88.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	except for the transcription of 2'-O-methylated templates, (rAm)n and (rCm)n, all other template-primers requires Mg2+ for optimal activity	HTLV-III

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
95000	98000	gel filtration	HTLV-III

Organism

Organism	UniProt	Comment	Textmining
HTLV-III	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	the enzyme transcribs (rA)n(dT)12, (rAm)n(dT)12, (rC)n(dG)12 and (rCm)n(dG)12. The enzyme catalyzes transcription of the 70S RNA from SSAV. (RC)n(dG)12-dependent activity is several fold higher than that catalyzed by (rA)n(dT)12 and is strictly Mg2+-dependent	HTLV-III	diphosphate + DNAn+1	-	?

pI Value

Organism	Comment	pI Value Maximum	pI Value
HTLV-III	the enzyme is heterogenous with two isoelectric points, 5.75 and 6.25	-	5.75
HTLV-III	the enzyme is heterogenous with two isoelectric points, 5.75 and 6.25	-	6.25

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Release 2023.1 (January 2023)