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Literature summary for 2.7.7.49 extracted from

  • Lavignon, M.; Bertrand, J.R.; Rayner, B.; Imbach, J.L.; Malvy, C.; Paoletti, C.
    Inhibition of Moloney murine leukemia virus reverse transcriptase by alpha-anomeric oligonucleotides (1989), Biochem. Biophys. Res. Commun., 161, 1184-1190.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-amomeric oligonucleotides inhibit reaction with either homopolymeric or heteropolymeric substrates Moloney murine leukemia virus
alpha-d(A)15 0.032 mM, inhibits 50% of the RNA dependent DNA polymerase activity, reaction with poly(U) as template Moloney murine leukemia virus
alpha-d(T)16 0.08 mM, 50% inhibition of RNA dependent DNA polymerase activity when 0.0075 mM beta-pd(T)12-18 as primer, poly(A) as template Moloney murine leukemia virus

Organism

Organism UniProt Comment Textmining
Moloney murine leukemia virus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
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Moloney murine leukemia virus diphosphate + DNAn+1
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