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Literature summary for 2.7.7.48 extracted from

  • Cakir, G.; Kuecuekguezel, I.; Guhamazumder, R.; Tatar, E.; Manvar, D.; Basu, A.; Patel, B.A.; Zia, J.; Talele, T.T.; Kaushik-Basu, N.
    Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase (2015), Arch. Pharm., 348, 10-22.
    View publication on PubMed
Search for more literature for 2.7.7.48

Inhibitors

Inhibitors Comment Organism Structure
2-([5-(2,4-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one
-
 Hepacivirus C
2-([5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one
-
 Hepacivirus C
2-([5-(2-chloro-6-fluorophenyl)-1,3,4-thiadiazol-2-yl]-imino)-1,3-thiazolidin-4-one
-
 Hepacivirus C
2-([5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one
-
 Hepacivirus C
2-([5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one
-
 Hepacivirus C
2-([5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one
-
 Hepacivirus C
2-([5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(2,6-dichlorobenzylidene)-2-[[5-(2,4-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(2,6-dichlorobenzylidene)-2-[[5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(2,6-dichlorobenzylidene)-2-[[5-(2-chloro-6-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(2,6-dichlorobenzylidene)-2-[[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(2,6-dichlorobenzylidene)-2-[[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(2,6-dichlorobenzylidene)-2-[[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(2,6-dichlorobenzylidene)-2-[[5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(3-fluorobenzylidene)-2-[[5-(2,4-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(3-fluorobenzylidene)-2-[[5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(3-fluorobenzylidene)-2-[[5-(2-chloro-6-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(3-fluorobenzylidene)-2-[[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(3-fluorobenzylidene)-2-[[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(3-fluorobenzylidene)-2-[[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
5-(3-fluorobenzylidene)-2-[[5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one
-
 Hepacivirus C
additional information synthesis and evaluation of 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase, docking study and molecular modelling, overview Hepacivirus C

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Hepacivirus C

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Hepacivirus C
-
 diphosphate + RNAn+1
-
 ?
nucleoside triphosphate + RNAn Hepacivirus C NS5B
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-
Hepacivirus C NS5B
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Hepacivirus C diphosphate + RNAn+1
-
 ?
nucleoside triphosphate + RNAn
-
 Hepacivirus C NS5B diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
HCV NS5B polymerase
-
 Hepacivirus C

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Hepacivirus C