Literature summary for 2.7.7.48 extracted from

Wang, Y.K.; Rigat, K.L.; Sun, J.H.; Gao, M.; Roberts, S.B.
RNA template-mediated inhibition of hepatitis C virus RNA-dependent RNA polymerase activity (2008), Arch. Biochem. Biophys., 470, 146-152.

Search for more literature for 2.7.7.48

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Hepacivirus C

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibition of NS5B activity by RNA template exhibits characteristics of substrate inhibition, suggesting the template binds to a secondary site on the enzyme forming an inactive complex, poly(A) behaves like a competitive inhibitor with respect to oligo (dT12) primer	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Hepacivirus C

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Hepacivirus C	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
NS5B	-	Hepacivirus C
RDRP	-	Hepacivirus C
RNA-dependent RNA polymerase	-	Hepacivirus C

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Release 2023.1 (January 2023)