Literature summary for 2.7.7.48 extracted from

Lu, L.; Dekhtyar, T.; Masse, S.; Pithawalla, R.; Krishnan, P.; He, W.; Ng, T.; Koev, G.; Stewart, K.; Larson, D.; Bosse, T.; Wagner, R.; Pilot-Matias, T.; Mo, H.; Molla, A.
Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro (2007), Antiviral Res., 76, 93-97.

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Protein Variants

Protein Variants	Comment	Organism
D559G	mutant with decreased susceptibility for inhibitor A-837093	Hepacivirus C
G554D	mutant with decreased susceptibility for inhibitor A-837093	Hepacivirus C
S368A	mutant with decreased susceptibility for inhibitor A-837093	Hepacivirus C
Y448H	mutant with decreased susceptibility for inhibitor A-837093	Hepacivirus C
Y555C	mutant with decreased susceptibility for inhibitor A-837093	Hepacivirus C

Inhibitors

Inhibitors	Comment	Organism	Structure
2-([3-[1-(cyclobutylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]oxy)acetamide	A-782759	Hepacivirus C
N-[3-[(4R)-1-hydroxy-4-methyl-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide	A-837093	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	P26663	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Hepacivirus C	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
NS5B protein	-	Hepacivirus C
RNA-dependent RNA polymerase	-	Hepacivirus C

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Release 2023.1 (January 2023)